www.gcasneuro.com

Robert N. Gan, MD

Dr. Robert Gan is a qualified medical practitioner who is trained in Neurology and Cerebrovascular Diseases (Stroke) with an extensive experience in clinical trials, both as investigator and as sponsor medical advisor. As head of medical affairs in a pharmaceutical company, he was responsible for overseeing the conduct of clinical trials and analyses of data, collaborating with authors in publishing clinical studies, and guiding marketing, regulatory, and business operations. His invaluable experience in the clinics (in academic , public, and private settings) and in the pharmaceutical industry enables him to assess issues from multiple perspectives, provide specialized services that facilitate completion of projects, offer realistic and pragmatic advice on avoiding and preempting potential problems, and logically address complications encountered in clinical research, medical affairs and developmental plans.

Professional Experience

2018 - Consultant Neurologist, Fatima University Medical Center Antipolo, Philippines

2018 - Senior Advisor, [Pharmaceutical Company], Singapore

2012 - 2017 Head of Medical Affairs, [Pharmaceutical Company], Singapore

2009 - 2012 Clinical Research Scientist, Neurology (Stroke), [Pharmaceutical Company], Denmark

2008 - 2012 Regional Medical Manager, [Pharmaceutical Company], Asia-Pacific

2003 - 2008 Consultant Neurologist, National Neuroscience Institute, Singapore

1998 - 2004 Clinical Associate Professor of Neurology, University of the Philippines

1995 - 1997 Clinical Assistant Neurologist, Columbia-Presbyterian Medical Center

1994 - 1995 Chief Resident in Neurology, University of Chicago Medical Center

Training and Education

1995 - 1997 Post-doctoral Clinical Fellow in Stroke, Neurological Institute of New York, Columbia University

1992 - 1995 Resident in Neurology, University of Chicago Medical Center

1991 - 1992 Resident in Internal Medicine, St. Luke's\Roosevelt Hospital Center

1989 - 1990 Internship, Philippine General Hospital

1985 - 1990 Doctor of Medicine, University of the Philippines

1981 - 1984 B.S. Biological Sciences (cum laude), University of the Philippines

Certifications

2003 - 2008 Registered, Singapore Medical Council and Singapore Specialist Accreditation Board

1999 Fellow, Philippine Neurological Association

1997 - 2007 Diplomate, American Board of Psychiatry and Neurology

1990 Philippine Medical Board

Peer-Reviewed Articles

Gan R, Noronha A. The medullary vascular syndromes revisited. Journal of Neurology 1995; 242:195-202.

Gan R, Sacco RL, Gu Q, et al. Testing the validity of the lacunar hypothesis. The Northern Manhattan Stroke Study experience. Neurology 1997; 48:1204-1211.

Sacco RL, Gan R, Boden-Albala B, et al. Leisure-time physical activity and ischemic stroke risk: The Northern Manhattan Stroke Study. Stroke 1998; 29:380-387.

Sacco RL, Boden-Albala B, Gan R, et al. Stroke incidence in white, black, and Hispanic residents of an urban community: The Northern Manhattan Stroke Study. American Journal of Epidemiology 1998; 147:259-268.

Steiner MM, Di Tullio MR, Rundek T, Gan R, et al. Patent foramen ovale size and embolic brain imaging findings among patients with ischemic stroke. Stroke 1998; 29:944-948.

Rundek T, Chen X, Steiner MM, Gan R, Boden-Albala B, Paik MC, Demarin V, Sacco RL. Predictors of the one-year stroke recurrence in the Northern Manhattan Stroke Study. Acta Clinica Croatia 1998; 37 (1):3-10.

Rundek T, Hartmann A, Mast H, Chen X, Gan R, Demarin V, Sacco RL. Stroke subtype as a predictor of nursing home placement: Northern Manhattan Stroke Study. Acta Clinica Croatia 1998; 37 (3):175-180 .

Bautista FP, Ramos MA, San Jose CZ, Acero H, Manzanilla BM, Rocamora CJ, Abuel DE, Oris MY, and Gan R. Acute stroke in very old patients: Risk factors, subtypes and predictors of in-hospital mortality. Philippine Journal of Internal Medicine 2000; 38:188-191.

Yu RF, San Jose MCZ, Manzanilla BM, Oris MY, and Gan R. Sources and reasons for delays in the care of acute stroke patients. Journal of the Neurological Sciences 2002; 199:49-54.

Gan R, Teleg RA, Florento L, Bitanga ES. Effect of increasing doses of aspirin on platelet aggregation among stroke patients. Cerebrovascular Diseases 2002; 14:252-255.

Jamora RDG, Kishi-Generao EM, Jr., Apaga NEP, San Jose MCZ, Bitanga ES, and Gan R. The ICH Score: Predicting mortality and functional outcome in an Asian population [Letter to the Editor]. Stroke 2003; 34:6-7.

San Jose MCZ, Apaga NEP, Florento L, and Gan R. Effects of aerobic exercise and training on coagulation, platelet aggregation, and plasma lipids. Vascular Disease Prevention 2005; 2:145-150.

Gan R, Lambert C, Jiao LT, Chan SY, Ramani NV, Chen C, Girotra S, Samama MM, Bousser MG. Danqi Piantan Jiaonang does not modify hemostasis, hematology, and biochemistry in normal subjects and stroke patients. Cerebrovascular Diseases 2008; 25:450-456.

Lim CCT, Gan R, Chan CL, Tan AWJ, Khoo JJC, Chia SY, Kao SL, Abisheganaden J, Sitoh YY. Severe hypoglycemia associated with an illegal sexual enhancement product adulterated with glibenclamide: MR imaging findings. Radiology 2009; 250:193-201.

Ratchford EV, Jin Z, DiTullio MR, Salameh MJ, Homma S, Gan R, Boden-Albala B, Sacco RL, Rundek T. Carotid bruit for detection of hemodynamically significant carotid stenosis: The Northern Manhattan Study. Neurological Research 2009; 31:748-752.

Chen C, Venketasubramanian N, Gan RN, Lambert C, Picard D, Chan BPL, Chan E, Bousser MG, Shi XM. Danqi Piantang Jiaonang (DJ), a traditional Chinese medicine, in post-stroke recovery. Stroke 2009; 40:859-863.

Venketasubramanian N, Chen CLH, Gan RN, Chan BPL, Chang HM, Tan SB, Picard D, Navarro JC, Baroque AC II, Poungvarin N, Donnan GA, Bousser MG on behalf of the CHIMES Investigators. A double-blind, placebo-controlled, randomized, multicenter study to investigate CHInese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES Study). International Journal of Stroke 2009; 4:54-60.

Wasay M, Kaul S, Menon B, Venketasubramanian N, Gunaratne P, Khalifa A, Poungvarin N, Saadatnia M, Gan RN, Dai A, Mehndiratta MM. Ischemic stroke in young Asian women: Risk factors, subtypes and outcome. Cerebrovascular Diseases 2010; 30:418-422.

Agustin SJU, Yumul MP, Kalaw AJL, Teo BC, Eng J, Phua Z, Singh R, Gan RN, Venketasubramanian N. Effects of Posture on Right-to-Left Shunt Detection by Contrast Transcranial Doppler. Stroke 2011; 42:2201-2205.

Venketasubramanian N, Chan BPL, Chang HM, Chua HC, Gan RN, Hui F, Lee W, Ng I, Sharma VK, Singh R, Toeh HL, Wang E, Chen CLH. Brain Attack: Needing resuscitation. Singapore Medical Journal 2011; 52:620-630.

Fabiaña NL, Lee CF, Gan R, Venketasubramanian N, Wong KSL, Bousser M-G, Chen CPLH, De Silva DA, for the CHIMES Study Investigators. Using the full span of the SPAN-100 index to predict functional outcome in the CHIMES Study [Letter to Editor]. Int J Stroke 2015;10:E21.

Narayanaswamy Venketasubramanian N, Kumar R, Soertidewi L, Abu Bakar A, Laik C, Gan R. The NeuroAiD Safe Treatment (NeST) Registry: a protocol. BMJ Open 2015;5:e009866. doi:10.1136/bmjopen-2015-009866.

Kumar K, Htwe O, Baharudin A, Ariffin MH, Abdul Rhani S, Ibrahim K, Rustam A, Gan R. Spinal Cord Injury—Assessing Tolerability and Use of Combined Rehabilitation and NeuroAiD (SATURN Study): Protocol of An Exploratory Study In Assessing the Safety and Efficacy of NeuroAiD Amongst People Who Sustain Severe Spinal Cord Injury. JMIR Res Protoc 2016;5(4):e230.

Jamora RDG, Corral EV, Ang MA, Collantes MEV, Gan R. Stroke recurrence among Filipino patients taking aspirin for first-ever non-cardioembolic ischemic stroke. Neurol Clin Neurosci 2017:1-5. doi:10.1111/ncn3.12133.

Philippine Neurological Association One Database – Stroke (PNA1DB) Disease Study Management Group. Multi-center collection of uniform data on patients hospitalized for transient ischemic attack or stroke in the Philippines – The Philippine Neurological Association One Database - Stroke (PNA1DB-Stroke) protocol. BMJ Open 2022; 12:e055954. doi:10.1136/bmjopen-2021-055954.

Venketasubramanian N, Agustin SJ, Padilla JL, Yumul MP, Sum C, Lee SH, Ponnudurai K, Gan RN. Comparison of different laboratory tests to identify “aspirin resistance” and risk of vascular events among ischaemic stroke patients. J Cardiovasc Dev Dis 2022; 9:156. doi: 10.3390/jcdd9050156.

Books, Handbooks, Monographs

Gan R, Ramani NV (Editors). The Stroke Clinician’s Handbook. A practical guide to the care of stroke patients. World Scientific Publishing Co 2008.

Project Manager. De Silva DA, Venketasubramanian N, Roxas AA Jr, Loh PK, Lampl Y (Editors). Understanding Stroke. A guide for stroke survivors and their families. 2014. [electronic book]

Abstracts Presented/Published

Gan R, Gu Q, Boden-Albala B, Roberts JK, Kargman DE, Sacco RL. Stroke in Young Adults in Northern Manhattan: Incidence Rates, Subtypes, and Case Fatality [abstract]. Neurology 1996; 46 (suppl 1):A412.

Kargman DE, Berglund LF, Gu Q, Boden-Albala B, Gan R, et al. High Density Lipoprotein: A Potentially Modifiable Stroke Risk Factor: The Northern Manhattan Stroke Study [abstract]. Neuroepidemiology 1996; 15:282.

Gan R, Gu Q, Kargman DE, et al. Lacunar Syndromes, Small Deep Infarcts, and Final Diagnosis of Lacunar Stroke Mechanism: The Northern Manhattan Stroke Study [abstract]. Stroke 1997; 28:235.

Di Tullio MR, Gan R, Savoia MT, et al. Correlation Between Aortic Arch Atheromas, Presenting Clinical Syndrome and Infarct Size in Elderly Stroke Patients [abstract]. Stroke 1997; 28:238.

Roberts JK, Omarali I, Di Tullio MR, Sciacca RR, Gan R, et al. Age-Dependent Stroke Risk of Valvular Strands [abstract]. Stroke 1997; 28:241.

Sacco RL, Lin IF, Boden-Albala B, Kargman DE, Gan R, et al. Alcohol and the Risk of Ischemic Stroke: Verification of a J-shaped Relationship from the Northern Manhattan Stroke Study [abstract]. Stroke 1997; 28:250.

Martins-Castro LH, Gan R, Boden-Albala B, Sacco RL. The Spectrum of Potential Stroke Mechanisms in Small Deep Infarcts [abstract]. Neurology 1997; 48 (suppl 1):A373.

Halim A, Ottman R, Logroscino G, Gan R, et al. Familial Aggregation of Ischemic Stroke in the Northern Manhattan Stroke Study [abstract]. Neurology 1997; 48 (suppl 1): A161.

Elkind MS, Chen X, Lin IF, Boden-Albala B, Gan R, et al. Atrial Fibrillation is an Independent Predictor of Three-year Mortality after Ischemic Stroke [abstract]. Neurology 1997; 48 (suppl 1):A161.

Steiner MM, Chen X, Rundek T, Gan R, et al. Neuroradiologic Findings in Ischemic Stroke Patients with Patent Foramen Ovale: The Northern Manhattan Stroke Study [abstract]. Cerebrovascular Diseases 1997; 7 (suppl 4):35.

Rundek T, Chen X, Steiner MM, Gan R, et al. Predictors of 1-year Recurrence: The Northern Manhattan Stroke Study [abstract]. Cerebrovascular Diseases 1997; 7 (suppl 4):68.

Steiner MM, Rundek T, Chen X, Gan R, et al. The Impact of Ischemic Stroke on Quality of Life: The Northern Manhattan Stroke Study [abstract]. European Journal of Neurology 1997; 4.

Gan R, Lin IF, Sacco RL. Clinical History and Brain Imaging Features in Cardioembolic and Atherosclerotic Strokes [abstract]. Annals of Neurology 1997; 42:434-5.

Dennis LJ, Gan R, Mohr JP. Massive Posterior Inferior Cerebellar Artery Infarction and Brainstem Compression with Benign Clinical Course [abstract]. Annals of Neurology 1997; 42:441.

Gan R, Rundek T, Chen X, Sacco RL. Auscultation for Carotid Bruit: How useful is it? [abstract]. Philippine Journal of Neurology 1997; 3:73.

Rundek T, Chen X, Hartman A, Gan R, et al. Stroke Syndrome as a Predictor of Nursing Home Placement: The Northern Manhattan Stroke Study [abstract]. Stroke 1998; 29:321.

Gan R, Rundek T, Boden-Albala B, et al. Utility of Ausculation for Carotid Bruit in the Detection of Significant Carotid Stenosis [abstract]. Neurology 1998; 50 (suppl 4):A36.

Maravilla LM, Magsombol EB, Collado F, Cuanang J, and Gan R. Stroke Risk Factors and Intracranial Stenosis among Stroke-free Asians [abstract]. (Presented at the 8th Meeting of the Neurosonology Research Group of the World Federation of Neurology and Asian Symposium on Stroke Prevention and Treatment, November 2-6, 1999, Taipei, Taiwan). Acta Neurologica Taiwanica 1999; 8 (suppl 1):22

Gan R, Acero H, Manzanilla B, et al. The Stroke Data Bank: Preliminary Results at 1 Year [abstract]. (Presented at the 10th Asian and Oceanian Congress of Neurology, January 22-26, 2000, Manila, Philippines).

Gan R, Manzanilla B, Abuel D, Acero H. Stroke in Young Adults: Experience from the Stroke Data Bank [abstract]. (Presented at the 10th Asian and Oceanian Congress of Neurology, January 22-26, 2000, Manila, Philippines).

Gan R, Teleg RA, Florento L, Bitanga ES. Effect of Increasing Doses of Aspirin on Platelet Aggregation among Stroke Patients [abstract]. (Presented at the 10th Asian and Oceanian Congress of Neurology, January 22-26, 2000, Manila, Philippines).

San Jose MCZ, Acero H, Manzanilla, B, Abuel D, Rocamora C, Oris M, and Gan R. Stroke in Young Adults: Risk Factors, Subtypes and Outcome. Experience from the St. Luke's Medical Center Stroke Data Bank [abstract]. Stroke 2000; 31:2787.

Manalo LTV, Rivera EJB, Gan RN, et al. Carotid Duplex in the Detection of Carotid Artery Disease. Chest 2001; 120 (suppl 4):242S.

San Jose MCZ, Apaga NEP, Florento L, and Gan R. Effects of Aerobic Exercise and Training on Coagulation, Platelet Aggregation, and Plasma Lipids [abstract]. Stroke 2002; 33:389.

Gan R, Collantes E, Gumban L, et al. Aspirin Dose Optimized in Non-Cardioembolic Ischemic Stroke (ADONIS) [abstract ongoing clinical trial]. (27th International Stroke Conference, 7-9 February 2002, San Antonio, Texas).

Jamora RD, Corral E, Collantes E, Gan R. Stroke Recurrence among Filipino Patients on Aspirin for First-ever Non-cardioembolic Ischemic Stroke. (5th World Stroke Congress, 23-26 June 2004, Vancouver BC, Canada).

Soon SP, Yap LS, Verzola BA, Ng SK, Ong PT, Seah SH, Yumul M, Agustin SJ, Ramani NV Gan R. Effect of long Chinese festivals on stroke trials recruitment rates. (International Clinical Trials Symposium, 23-26 September 2007, Sydney, Australia)

Soon SP, Yap LS, Verzola BA, Ng SK, Ong PT, Seah SH, Yumul M, Agustin SJ, Venketasubramanian N, Gan R. Rates and timing of patient recruitment into secondary stroke prevention clinical trials. (5th Asia Pacific Conference Against Stroke, 13-15 March 2008, Manila, Philippines)

Ng SK, Ong PT, Soon SP, Yap LS, Verzola BA, Yumul M, Agustin SJ, Venketasubramanian N, Gan R. Demographics and risk factor profile of stroke patients who participated in secondary stroke prevention clinical trials. (5th Asia Pacific Conference Against Stroke, 13-15 March 2008, Manila, Philippines)

Verzola BA, Yumul M, Yap LS, Soon SP, Ng SK, Ong PT, Agustin SJ, Venketasubramanian N, Gan R. Use of antiplatelet, ACE inhibitor, and statin as markers of standard of care prior to recruitment among stroke patients who participated in clinical trials. (5th Asia Pacific Conference Against Stroke, 13-15 March 2008, Manila, Philippines)

Agustin SJ, Padilla JL, Yumul MP, Ong PT, Sum C, Kuperan P, Lee SH, Venketasubramanian N, Gan R. The use of different laboratory parameters to estimate the prevalence of “aspirin resistance” among patients with first-ever and recurrent non-cardioembolic ischemic stroke. (XVII European Stroke Conference, 13-16 May 2008, Nice, France)

Yumul MP, Gan R, Agustin SJ, Teo BC, Eng J, Koh WC, Venketasubramanian. Comparison of intracranial hemodynamic indices obtained by transcranial Doppler and by transcranial color-coded imaging. (XVII European Stroke Conference, 13-16 May 2008, Nice, France)

Wasay M, Kaul S, Ramani N, Gunaratne P, Menon B, Khalifa A, Poungvarin N, Saadatnia M, Gan R, Dai A, Mehndiratta M. Stroke in Young, Asian Women: Risk Factors, Subtypes, Presentation and Outcome. (61^st Annual Meeting of the American Academy of Neurology, 25 April – 2 May 2009, Seattle, WA, USA; and Combined Meeting of the 6th Asia Pacific Conference Against Stroke and the 20th Stroke Society of Australasia, 6‐10 September 2009, Cairns, Australia)